Apoptosis Reagents and Kits
Abcam Human PPIB (Cyclophilin B) knockout HeLa cell lysate.
Human PPIB (Cyclophilin B) knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human CD9 knockout HeLa cell lysate.
Human CD9 knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human MLH1 knockout A549 cell lysate.
Human MLH1 knockout A549 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human OAS1 knockout A549 cell lysate.
Human OAS1 knockout A549 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human HIST1H1C (Histone H1.2) knockout A549 cell lysate.
Human HIST1H1C (Histone H1.2) knockout A549 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human SRSF5 knockout HEK-293T cell lysate.
Human SRSF5 knockout HEK-293T cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Flavokawain C | 37308-75-1 | MFCD00016489 | 99.5% | 300.31 g/mol | C17H16O5 | 10 MG
Flavokawain C is a naturally occurring chalcone isolated from Kava root that exhibits cytotoxic activity against human cancer cell lines (reported IC50 12.75 μM for HCT-116). It is supplied for research use and commonly used in in vitro studies of apoptosis, cell proliferation, and mechanism-of-action investigations.
- Natural chalcone with reported apoptosis-inducing activity.
- Reported IC50 12.75 μM against HCT-116 cells.
- Molecular formula C17H16O5; molecular weight ~300.31 g/mol.
- High reported purity (~99.5%).
- Solid, light yellow to orange; store protected from light.
- Available in small mg package sizes suitable for laboratory research.
Abcam Human CCND1 (Cyclin D1) knockout HeLa cell lysate.
Human CCND1 (Cyclin D1) knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical BIotIn-VAD-FMK 1mg
A biotin-conjugated caspase inhibitor; an affinity probe that allows for detection and immobilization of caspases using the biotin ligand; inhibits caspase-3-like activity in a dose-dependent manner in hepatocytes stimulated with TNF-α and ActD; binds to caspase-3 and caspase-8 in hepatocyte lysates
Abcam Human GSN (Gelsolin) knockout HeLa cell lysate.
Human GSN (Gelsolin) knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human BCL10 knockout HeLa cell lysate.
Human BCL10 knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human EIF2AK4 (GCN2) knockout HEK-293T cell lysate.
Human EIF2AK4 (GCN2) knockout HEK-293T cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human NOTCH1 knockout HeLa cell lysate.
Human NOTCH1 knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen SP600125
Chemical. CAS 129-56-6. Formula C14H8N2O. MW 220.2. SP600125 is an orally active, reversible and ATP-competitive broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 IC50 = 40nM, 40nM and 90nM, respectively. In Jurkat T cells, SP600125 suppressed the phosphorylation of c-Jun with IC50 of 5-10 µM. It has 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB and PKCalpha, and 100-fold selectivity against ERK2, p38, Chk1, EGFR. SP600125 is also a broad-spectrum inhibitor of serine/threonine kinases including hydrocarbon receptor AhR, Mps1, Aurora kinase A, FLT3 and TRKA. SP600125 inhibits cell cycle, autophagy and ferroptosis and activates apoptosis. It shows anti-inflammatory activity by inhibiting the expression of inflammatory genes such as COX-2, IL-2 IFN-gamma and TNF-alpha and has antiviral and neuroprotective properties.
AdipoGen m-3M3FBS
Chemical. CAS 200933-14-8. Formula C16H16F3NO2S. MW 343.4. m-3M3FBS is a cell permeable and specific activator of phospholipase C PLC that has been shown to stimulate the PLC-mediated intracellular Ca2 release, inositol phosphates production and superoxide generation in various cell types. It activates all PLC isotypes beta2, beta3, gamma1, gamma2 and delta1 in vitro, but not heterotrimeric G proteins, PI 3-kinase or PLD. m-3M3FBS also affects calcium homeostasis independently of PLC activation. m-3M3FBS induces apoptosis in tumor cells through caspase activation, down-regulation of XIAP and intracellular calcium signaling. m-3M3FBS has been shown in vitro to trigger mitochondrial damage and activate NLRP10 a bona fide inflammasome binding to Asc and Caspase-1 in keratinocytes. NLRP10 acts also as inflammasome in intestine epithelial cells and protects against autoinflammation in the gut.