Apoptosis Reagents and Kits
Abcam Human GAS6 knockout HEK-293 cell lysate.
Human GAS6 knockout HEK-293 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC EPI-743 (α-Tocotrienol quinone) | 1213269-98-7 | 98.1% | 440.66 | 5 MG
EPI-743 (α-Tocotrienol quinone), also known as Vatiquinone, is a potent cellular oxidative stress protectant and ferroptosis inhibitor. It is a synthetic analog of vitamin E, used in the study of mitochondrial diseases, and targets the repletion of reduced intracellular glutathione.
- Potent cellular oxidative stress protectant
- Inhibits ferroptosis in cells
- Used for the study of mitochondrial diseases
- Synthetic analog of vitamin E
- Targets the repletion of reduced intracellular glutathione
- Oral activity
- Prevents RSL3-induced ferroptosis in PCH6 patient fibroblasts
- Prevents BODIPY 581/591 C11 lipid oxidation
- Inhibits RSL3-mediated ferroptotic cell death in B-lymphocytes
ABclonal Technology Annexin A6/Annexin VI
Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways The annexin VI gene is approximately 60 kbp long and contains 26 exons It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths It is highly similar to human annexins I and II sequences each of which contain four such repeats Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis Alternatively spliced transcript variants have been described
ABclonal Technology Caspase-6 Rabbit mAb
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits large and small that dimerize to form the active enzyme This protein is processed by caspases 7 8 and 10 and is thought to function as a downstream enzyme in the caspase activation cascade Alternative splicing of this gene results in multiple transcript variants that encode different isoforms
ABclonal Technology Caspase-12 Rabbit mAb
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines In rodents the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress However in humans this gene contains a polymorphism for the presence or absence of a premature stop codon The majority of human individuals have the premature stop codon and produce a truncated non-functional protein The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis Several alternatively spliced transcript variants have been noted for this gene
Abcam Mouse CDKN1B (p27 KIP 1) knockout RAW 264.7 cell lysate.
Mouse CDKN1B (p27 KIP 1) knockout RAW 264.7 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human OAS1 knockout HeLa cell lysate.
Human OAS1 knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human EPCAM knockout A-431 cell lysate.
Human EPCAM knockout A-431 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical DmyoInosItol phsphat Scre 50uL
An inhibitor of wild-type and mutant EGFR (IC50s 1.07 0.46 0.13 0.26 and 0.19 nM for wild-type EGFR EGFRd746-750/T790M/C797S EGFRL858R/T790M/C797S EGFRd746-750/T790M and EGFRL858R/T790M respectively) inhibits the proliferation of wild-type EGFR-expressing A431 EGFRd746-750/T790M/C797S-expressing Ba/F3 EGFRd746-750/T790M/C797S-expressing H1975 and EGFRd746-750-expressing PC-9 cells (IC50s 147 26.8 163 and 45 nM respectively) reduces tumor growth in triple mutant EGFR mouse xenograft models
Abcam Human NPC2 (Niemann Pick C2) knockout HEK-293T cell lysate.
Human NPC2 (Niemann Pick C2) knockout HEK-293T cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human VRK1 knockout HEK-293T cell lysate.
This product is for research use only and not for diagnostic or therapeutic procedures. Customer is granted a limited, non-exclusive license for internal research and shall not attempt to reverse engineer.
Human VRK1 knockout HEK-293T cell lysate.
Abcam Human HLA-E (HLA E) knockout HEK-293T cell lysate.
Human HLA-E (HLA E) knockout HEK-293T cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human WDR4 knockout HeLa cell lysate.
Human WDR4 knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human PRKRA (PACT) knockout HEK-293T cell lysate.
Human PRKRA (PACT) knockout HEK-293T cell lysate.
The product is subject to the following: Abcam Restricted Use Statement